Hyperemesis Gravidarum

What causes hyperemesis gravidarum?

Healthcare providers don't know what causes hyperemesis gravidarum. It may be related to pregnancy hormones. 

Who is at risk for hyperemesis gravidarum?

The condition is more common in women who are pregnant with twins or more. It’s also more common in women with migraines. Women with a family history of the condition or who had the condition in a past pregnancy are more likely to have it with future pregnancies.

What are the symptoms of hyperemesis gravidarum?

These are the most common symptoms:

• Constant nausea, especially during the first trimester
• Vomiting after eating or drinking
• Vomiting not linked to eating
• Weight loss. This is especially true if it is 5% or more of what you weighed before pregnancy.
• Signs of fluid loss (dehydration). These include dry mouth, thirst, small amounts of dark urine, and feeling lightheaded.

The symptoms may look like other health conditions. Always see your healthcare provider for a diagnosis.

How is hyperemesis gravidarum diagnosed?

Your healthcare provider will review your health history and do a physical exam. They will also look for other signs, such as weight loss and dehydration. Blood tests can check for too little or too much of the body's minerals (electrolytes).

How is hyperemesis gravidarum treated?

Treatment aims to:

• Ease nausea and vomiting
• Replace fluids and electrolytes
• Improve nutrition and weight gain

You will likely need to stay in the hospital. All food and drink are stopped for a short time (temporarily). This gives the digestive tract a rest. You will often need IV (intravenous) fluids to replace fluids you have lost. The IV fluids also fix problems with minerals (electrolytes) in your body. You may need a sedative and antivomiting medicine. If other treatments don't work, you may need steroids or tube feedings.

What are possible complications of hyperemesis gravidarum?

The condition can lead to:

• Fluid and electrolyte problems
• Poor nutrition
• Liver damage and yellowing of the skin, eyes, and mucous membranes (jaundice)
• B vitamin (thiamine) deficiency  
• Poor growth of the developing baby

Key points about hyperemesis gravidarum

• This condition is a severe form of nausea and vomiting of pregnancy that affects a small number of women.
• Nausea and vomiting may be constant. You may lose weight, get dehydrated, and have changes in the body's chemicals (electrolytes).
• The cause may be linked to pregnancy hormones. 
• It is more common in women who are pregnant with twins or more, and in women with migraines.
• You may need to stay in the hospital for treatment. You will often need IV fluids to replace fluids you have lost.

Next steps

Tips to help you get the most from a visit to your healthcare provider:

• Know the reason for your visit and what you want to happen.
• Before your visit, write down questions you want answered.
• Bring someone with you to help you ask questions and remember what your provider tells you.
• At the visit, write down the name of a new diagnosis, and any new medicines, treatments, or tests. Also write down any new instructions your provider gives you.
• Know why a new medicine or treatment is prescribed, and how it will help you. Also know what the side effects are.
• Ask if your condition can be treated in other ways.
• Know why a test or procedure is recommended and what the results could mean.
• Know what to expect if you do not take the medicine or have the test or procedure.
• If you have a follow-up appointment, write down the date, time, and purpose for that visit.
• Know how you can contact your healthcare provider if you have questions, especially after office hours or on weekends.